Most of the plants protect their leaves, flowers and fruits with resinous substances that they produce against antimicrobial rot, which have waterproof and thermal insulation properties. Honey bees collect these resinous substances from cracks, buds and leaves in the trunks of trees. The sticky substance, which the bees chew, mix with the digestive enzymes and partially digest, mixes with beeswax and is used for various purposes in the hive. In other words, propolis honey bees; It is a sticky, dark substance that it collects from living plants, mixes with wax and is used for polishing and closing the openings in the hive before laying eggs in the larval eyes. Propolis plays color from yellow to dark brown and sometimes green. The color of propolis varies according to the region and season. For example, examples of countries with a mild climate have more or less pronounced brown, while in countries with tropical climates and Australia, propolis is black in color. Finnish propolis is orange and Cuban propolis is dark violet. Due to the change in the botanical origin of propolis, it is natural to observe differences in color. The chemical content of propolis is very complex and varies depending on the flora of the region where it is collected. Depending on the species and density of plants grown in different ecosystems, the chemical content of propolis obtained from these regions varies. In addition to the local flora, the content of propolis also varies depending on the conditions of flowering, climatic conditions, the amount of resin in the bud, the time of collection, the content of the substance secreted by beeswax, pollen and bee.